The order of the comics in the list is mostly accidental, and does in no way reflect their quality. These links are here because I like them all.
My daily dose:
Sluggy Freelance, by Pete Abrams
Sinfest, by Tatsuya Ishida
Schlock Mercenary, by Howard Tayler
User Friendly, by J.D. "Illiad" Frazer
Kevin and Kell, by Bill Holbrook
Weekdays
Wapsi Square, by Paul Taylor
Poisoned Minds, by Alan Foreman
Updated M-W-F (that's Monday-Wednesday-Friday for you)
Jack, by David Hopkins
MegaTokyo, by Fred Gallagher and Rodney Caston
Freefall, by Mark Stanley
Errant Story, by Michael Poe
Marilith (AKA Krakow V3.0), by Krazy Krow
Girl Genius, by Phil and Kaja Foglio
Updated on other exotic schedules:
College Roomies From Hell, by Maritza Campos
Something Positive, by R*K*Mulholland (updated a lot)
Clan of the Cats, by Jamie Robertson
Strangecandy, by Emi-Chan, Kourin and Tanzy
Krakow, by Krazy Krow (Monday)
Sabrina Online, by Eric W. Schwartz (first of the month)
Zortic, by Mark Mekkes
Sex and Violence, by Aaron M. Holm
Sexy Losers, by Clay aka Hard (Updating again, about once a month.)
Chopping Block, by Lee Adam Herold
HHOS comics
My First Dictionary, by Ross Horsley
Pictures for Sad Children, by John Campbell
Not updated currently, but still worth reading the archives:
Cigarro & Cerveja, by Tony Esteves
You Damn Kid, by Owen Dunne
The Suburban Jungle, by John "The Gneech" Robey
Never Never, by John "The Gneech" Robey
Ghastly's Ghastly Comic, by Ghastly (Taking a break)
Krazy Larry, by Paul Southworth (Aaargh, the domain is gone!)
Deep Fried, by Jason Yungbluth
Road Waffles, by Eight
Queen of Wands, by Aeire (the story is over)
RPG World, by Ian Jones-Quartey (on an indefinite hiatus)
Surf Rat and Spencer, by Kyle Goodman (waiting)
Joe Average, by Aaron M. Holm (cancelled due to emotional stress)
Lizard, by Dave Kelly (Xref "Living in Greytown", the story is over)
Captain Mooki, by Teague Tysseling (moved to "premium")
Krakow v2.0, by Krazy Krow (the story continues at Marilith)
Exploitation Now, by Michael Poe (the story is over)
Living in Greytown, by Dave Kelly (the story is over)